Caffeine is toxic in high enough doses. It is unlikely though, that a toxic dose will be ingested in form of common drinks. In concentrated forms such as pills or powders it can be taken in sufficient quantities to cause vomiting, unconsciousness, and even death. A single box of caffeine pills can be fatal if taken at one time.
The fineness of the grounds has a major impact on flavour, with finer grinding leading to a more intense and full flavour. The main reason to use coarser grounds is simply to prevent the grounds from being pushed through coarser filter types (such as the cafetière).
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